Joint Care: Koyosamine® HCl (90 Capsules)

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Quick Overview

A highly purified Glucosamine like no others… • Extracted through proprietary refinery process from Crustacean shells • Patented • Provides strength to cartilage • Supports joint health and mobility • Relieves joint discomfort and pain • Anti-inflammatory effect • Fast-acting • Clinically tested effective and safe Manufactured in Japan



Koyosamine® HCL is a patented and highly purified glucosamine  extracted from shells of Crustacea (crabs and shrimps) through a proprietary refinery process. It is manufactured in Japan with comprehensive quality program compliance to Food cGMP, ISO 9001 and FSSC 22000

Koyosamine® HCL has been clinically studied to be safe and effective in maintaining a properly-functioning joint structure. It not only serves as a prominent building block and lubricant to enhance the strength, softness, elasticity and integrity of the joint cartilage and connective tissue, it also has the anti-inflammatory effect to prevent tissue injury and pain. 

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Clinical Studies

Clinical Studies

1. Efficacy of Koyosamine® HCL for the treatment of osteoarthritis of the knee

Koyosamine® HCL showed significant and dose-dependent therapeutic improvement in 50 patients with knee osteoarthritis after 8-week treatment. [Journal of Japanese Society of Clinical Nutrition, 20(1), 41-47, 1998]



2. Healing effect on injured cartilage

Rabbits with joint cartilage damage showed complete recovery after 3-week treatment with Koyosamine® HCL. [Carbohydrate Polymers, 48, 369-378, 2002]



3. Effect of Koyosamine® HCL on adjuvant arthritis in rats


Treatment with 300mg/d Koyosamine® HCL for 3 weeks significantly suppressed the rapid increase in arthritis score, indicating a positive effect of Koyosamine® HCL on inflammatory arthritis. [Inflammation Research, 54(3), 127-132, 2005]


Treatment with Koyosamine® HCL significantly suppressed the increase of arthritis score.

4. Improvement on Skin Texture

Dry and rough skin became smooth and reduced wrinkles just after 6-week of Koyosamine® HCL intake.

Improvement on Skin Texture